mGluR6 deletion renders the TRPM1 channel in retina inactive
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چکیده
منابع مشابه
mGluR6 deletion renders the TRPM1 channel in retina inactive.
In darkness, glutamate released from photoreceptors activates the metabotropic glutamate receptor 6 (mGluR6) on retinal ON bipolar cells. This activates the G protein G(o), which then closes transient receptor potential melastatin 1 (TRPM1) channels, leading to cells' hyperpolarization. It has been generally assumed that deleting mGluR6 would render the cascade inactive and the ON bipolar cells...
متن کاملNeurophysiol and Noga Vardi Ying Xu , Anuradha Dhingra , Marie E . Fina , Chieko Koike , Takahisa Furukawa inactive mGluR 6 deletion renders the TRPM 1 channel in retina
inactive mGluR6 deletion renders the TRPM1 channel in retina You might find this additional info useful...
متن کاملUltrastructural localization and expression of TRPM1 in the human retina.
PURPOSE Transient receptor potential subfamily melastatin (TRPM)1 cation channels of retinal ON-bipolar cells are modulated via a mGluR6 (GMR6) signaling cascade. While light-microscopy shows these channels are located on the tips of ON-bipolar cells dendrites, near rod and cone synaptic ribbons, TRPM1 localization at the electron-microscope level is currently not described. The authors report ...
متن کاملThe TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go
Transmission from photoreceptors to ON bipolar cells in mammalian retina is mediated by a sign-inverting cascade. Upon binding glutamate, the metabotropic glutamate receptor mGluR6 activates the heterotrimeric G-protein Gαoβ3γ13, and this leads to closure of the TRPM1 channel (melastatin). TRPM1 is thought to be constitutively open, but the mechanism that leads to its closure is unclear. We inv...
متن کاملTRPM1 is required for the depolarizing light response in retinal ON-bipolar cells.
The ON pathway of the visual system, which detects increases in light intensity, is established at the first retinal synapse between photoreceptors and ON-bipolar cells. Photoreceptors hyperpolarize in response to light and reduce the rate of glutamate release, which in turn causes the depolarization of ON-bipolar cells. This ON-bipolar cell response is mediated by the metabotropic glutamate re...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2012
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00933.2011